Habitat and intro: Chemical Constituents: Historical Use: Modern science: A significant anti-depressant effect of Albizia extract has been demonstrated, likely via the serotonin 5-HT1A receptor system[8] and GABA receptor system[9]. Albizia stem extracts have been shown to have potent antioxidant scavenging ability, up to 6 times stronger than vitamin C[10]. It has potent neuroprotective effects and has been shown to enhance mitochondrial function[11]. Some authors consider Albizia bark could be an anti-anxiety drug candidate[12]. Albizia bark has been shown to suppress tumor growth and angiogenesis[13][14][15]. Saponin fractions of Albizia have been shown to stimulate immune function[16]. Extracts of Albizia have been shown to be strongly anti-inflammatory via TNF-α-and NF-κB inhibition[17]. Clinical use: Suggested dose: Contraindications: [1] Chen and Chen, Chinese Medical Herbology, Art of Medicine Press, 2001, pg 768-769 [2] J Asian Nat Prod Res. 2008 Jul-Aug;10(7-8):781-5. doi: 10.1080/10286020802031056 [3] Xian Dai Zhong Yao Yao Li Xue (Contemporary Pharmacology of Chinese Herbs), 1997: 1097 [4] J. Nat. Prod., 1997, 60 (2), pp 102107 DOI: 10.1021/np960556t [5] Chen and Chen, Chinese Medical Herbology, Art of Medicine Press, 2001, pg 768-769 [6] Chinese Herbal Medicine Materia Medica (revised edition), Bensky, Gamble, & Kaptchuk [7] J Ethnopharmacol. 2000 Jul;71(1-2):321-3. [8] Pharmacol Biochem Behav. 2007 May;87(1):41-7. Epub 2007 Apr 6. [9] Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jul 1;44:184-92. doi: 10.1016/j.pnpbp.2013.02.012. [10] Arch Pharm Res. 2003 Jun;26(6):458-62. [11] Drug Chem Toxicol. 2017 Dec 18:1-8. doi: 10.1080/01480545.2017.1413106. [12] Molecules. 2017 Aug 11;22(8). pii: E1331. doi: 10.3390/molecules22081331. [13] Mol Med Rep. 2015 May;11(5):3405-13. doi: 10.3892/mmr.2015.3228. [14] Phytomedicine. 2009 Aug;16(8):703-11. doi: 10.1016/j.phymed.2009.01.002. [15] Chem Pharm Bull (Tokyo). 2006 Aug;54(8):1211-2. [16] Int Immunopharmacol. 2014 Oct;22(2):346-55. doi: 10.1016/j.intimp.2014.07.021. [17] Evid Based Complement Alternat Med. 2012;2012:983023. doi: 10.1155/2012/983023. [18] Chinese Herbal Medicine Materia Medica (revised edition), Bensky, Gamble, & Kaptchuk
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