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Glyphosate (Round Up) is a chemical that has been used as an herbicide since the 1970’s. Between the 1970’s and 2016 there has been a 100 times increase in its prevalence, and it is the most commonly used herbicide in the USA today. It is also routinely sprayed on many non-organic crops right before harvesting to help dry out the crops, and increase the harvest. In 2015 the World Health Organization classifi ed glyphosate as “probably carcinogenic in humans”. Glyphosate has been linked to increased intestinal permeability (leaky gut), causing chronic acidosis and mitochondrial dysfunction, altering normal glut fl ora, stimulating breast cancer cell growth, kidney damage, suppressing cytochrome P450 enzymes, and many other conditions (1, 2, 3, 4, 5, 6, 7). Many food products, including some organic ones, have been found to contain high levels of glyphosate residue (8).

One study was done to see if diff erent herbs could contribute protection against damage caused by glyphosphate. The compound contained both Taraxacum official (dandelion) and Arctium lappa (burdock), two components in Glypho-X. In the study glyphosate invoked liver cell death, but after treatment with the herbs, liver cell death decreased by up to 89% (9).

Taraxacum official (dandelion) has been shown to be hepato-protective (10, 11). One study showed taraxacum can lower total cholesterol, lower triglycerides, and increase HDL (12). Another study showed it can help prevent hypercholesterolemic atherosclerosis and lower ones risk for coronary artery disease (13). In addition to cardiovascular health taraxacum has been shown to have an anti-infl uenza viral eff ect (14). It also has antibacterial and anti-infl ammatory properties (15, 16). Arctium Lappa (burdock) is plant known for its detoxification properties (17). It acts as an anti-infl ammatory by decreasing infl ammatory cytokines, IL-6, and TNF-α (18). In addition to being shown to help protect against glyphosate induced liver damage, it has also been shown to be eff ective in helping protect against multiple other types of chemical induced liver damage (19, 20, 21).

Ocimum basilicum (basil leaf) is a great detoxifier and studies have shown it to increase phase II enzyme activity, being especially helpful with xenobiotic detoxification (22). Similar to taraxacum offi cial and arctiumlappa, basil helps to protect against chemical induced liver damage (23). It also has been shown to increase memory recall due to its antioxidant, fl avonoid, tannin, and terpenoid levels (24). Studies also show ocimum to possess antiviral, antibacterial, and antifungal properties (25, 26, 27).

Dosage:
We recommend taking 1 pill 3x per day for the fi rst bottle. After that it can be taken prophylactically as needed when eating foods that may have residue of glyphosate or other herbicides/pesticides.

Please consult your physician before taking if you have a bleeding disorder, are allergic to ragweed, or are pregnant.

References:
1. Vasiluk, Luba, Linda J. Pinto, and Margo M. Moore. "Oral bioavailability of glyphosate: studies using two intestinal cell lines." Environmental toxicology and chemistry 24.1 (2005): 153-160.

2. Swanson, Nancy L., Judy Hoy, and Stephanie Seneff. "Evidence that glyphosate is a causative agent in chronic sub-clinical metabolic acidosis and mitochondrial dysfunction." International Journal of Human Nutrition and Functional Medicine 4 (2016): 32-52.

3. Samsel, Anthony, and Stephanie Seneff. "Glyphosate’s suppression of cytochrome P450 enzymes and amino acid biosynthesis by the gut microbiome: pathways to modern diseases." Entropy 15.4 (2013): 1416-1463.

4. Shehata, Awad A., et al. "The effect of glyphosate on potential pathogens and beneficial members of poultry microbiota in vitro." Current microbiology66.4 (2013): 350-358.

5. Thongprakaisang, Siriporn, et al. "Glyphosate induces human breast cancer cells growth via estrogen receptors." Food and Chemical Toxicology 59 (2013): 129-136.

6. Jayasumana, Channa, Sarath Gunatilake, and Priyantha Senanayake. "Glyphosate, hard water and nephrotoxic metals: are they the culprits behind the epidemic of chronic kidney disease of unknown etiology in Sri Lanka?." International journal of environmental research and public health 11.2 (2014): 2125-2147.

7. Samsel, Anthony, and Stephanie Seneff. "Glyphosate’s suppression of cytochrome P450 enzymes and amino acid biosynthesis by the gut microbiome: pathways to modern diseases." Entropy 15.4 (2013): 1416-1463.

8. https://usrtk.org/wp-content/uploads/2016/11/FDN_Glyphosate_FoodTesting_Report_p2016-3.pdf

9. Gasnier, Céline, et al. "Dig1 protects against cell death provoked by glyphosate-based herbicides in human liver cell lines." Journal of Occupational Medicine and Toxicology 5.1 (2010): 29.

10. Al-Malki, Abdulrahman L., et al. "Hepatoprotective effect of dandelion (Taraxacum officinale) against induced chronic liver cirrhosis." Journal of Medicinal Plants Research 7.20 (2013): 1494-1505.

11. Davaatseren, Munkhtugs, et al. "Dandelion leaf extract protects against liver injury induced by methionine-and choline-deficient diet in mice." Journal of medicinal food 16.1 (2013): 26-33.

12. Cho, Soo-Yeul, et al. "Alternation of hepatic antioxidant enzyme activities and lipid profile in streptozotocin-induced diabetic rats by supplementation of dandelion water extract." Clinica Chimica Acta 317.1 (2002): 109-117.

13. Choi, Ung-Kyu, et al. "Hypolipidemic and antioxidant effects of dandelion (Taraxacum officinale) root and leaf on cholesterol-fed rabbits." International journal of molecular sciences 11.1 (2010): 67-78.

14. He, Wen, et al. "Anti-influenza virus effect of aqueous extracts from dandelion." Virology journal 8.1 (2011): 538.

15. Jeon, Hye-Jin, et al. "Anti-inflammatory activity of Taraxacum officinale." Journal of ethnopharmacology 115.1 (2008): 82-88.

16. Qian, Li, et al. "Preparation and antibacterial activity of oligosaccharides derived from dandelion." International journal of biological macromolecules64 (2014): 392-394.

17. Al-Snafi, Ali Esmail. "Detoxification capacity and protective effects of medicinal plants (part 2): plant based review." IOSR Journal of Pharmacy 6.7 (2016): 63-84.

18. Huang TC, Tsai SS, Liu LF, Liu YL, Liu HJ and Chuang KP. Effect of Arctium lappa L. in the dextran sulfate sodium colitis mouse model . World J Gastroenterol, 16(33), 2010, 4193-4199.
19. Lin SC, Chung TC, Lin CC et al. Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminopheninduced liver damage. American Journal of Chinese Medicine, 28, 2000, 163-173. 72.

20. Lin SC, Lin CH, Lin CC et al. Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride. J Biomed Sci, 9, 2002, 401-409.

21. El-Kott, Attalla Farag, and Mashael Mohammed Bin-Meferij. "Use of Arctium lappa extract against acetaminophen-induced hepatotoxicity in rats." Current Therapeutic Research 77 (2015): 73-78.

22. Dasgupta, T., A. R. Rao, and P. K. Yadava. "Chemomodulatory efficacy of basil leaf (Ocimum basilicum) on drug metabolizing and antioxidant enzymes, and on carcinogen-induced skin and forestomach papillomagenesis." Phytomedicine 11.2-3 (2004): 139-151.

23. George, Saramma. "An Evaluation of the Preventive Effect of the Methanol Extract of Thai Basil (Ocimum basilicum L.) on Ethanol-induced Hepatotoxicity in Rats." (2014).

24. Sarahroodi, Shadi, et al. "The effects of green Ocimum basilicum hydroalcoholic extract on retention and retrieval of memory in mice." Ancient science of life 31.4 (2012): 185.

25. Chiang, Lien‐Chai, et al. "Antiviral activities of extracts and selected pure constituents of Ocimum basilicum." Clinical and Experimental Pharmacology and Physiology 32.10 (2005): 811-816.

26. Adigüzel, Ahmet, et al. "Antimicrobial effects of Ocimum basilicum (Labiatae) extract." Turkish Journal of Biology 29.3 (2005): 155-160.

27. Oxenham, S. K., K. P. Svoboda, and D. R. Walters. "Antifungal activity of the essential oil of basil (Ocimum basilicum)." Journal of phytopathology 153.3 (2005): 174-180.

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